The association of prevalent medial meniscal pathology with cartilage loss in the medial tibiofemoral compartment over a 2-year period. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. A possible pathway for osteoarthritis pathology. Osteoarthritis chondrocytes die by apoptosis. Transcriptional profiling and pathway analysis of monosodium iodoacetate-induced experimental osteoarthritis in rats: relevance to human disease. Light-emitting diodes (LEDs) in dermatology. Effect of low-level laser therapy on the expression of inflammatory mediators and on neutrophils and macrophages in acute joint inflammation. CONCLUSION: These results suggest that the 840 nm LED irradiation would be a suitable non-thermal phototherapy for the treatment of OA, as a cartilage protection and anti-inflammatory modality.Īlves AC, Vieira RD, Leal-Junior EC, et al. In addition, LED irradiation showed an increase of collagen production in the meniscus. LED irradiation also reduced apoptosis of cartilage cells, but it prevented apoptosis of infiltrated inflammatory cells in synovium. In the histologic analysis, however, LED irradiation prevented cartilage damage and subchondral bone destruction, and significantly reduced mononuclear inflammatory cell infiltration and pannus formation. RESULTS: Radiographic examination could not show the differences between the MIA-treated and the MIA-LED-treated rats. Apoptotic cell in tissue sections was detected using TUNEL method.
Histologic analysis were performed following staining with hematoxylin and eosin, safranin O-fast green, or toluidine blue, picrosirius red, and histologic changes were scored according to a modified Mankin system. The assessment of OA induction were monitored by knee movement and radiographic finding. Knee joints were removed and fixed overnight in 10% neutral buffered formalin and decalcified by EDTA for 2 week before being embedded in paraffin.
To compare with the effect of LED irradiation, the indomethacin was administrated 20 mg/kg twice a week orally after 7 days of MIA treatment. The LED was irradiated for 15 min/day for a week after 7 days of MIA treatment. Vehicle control rats were injected with an equivalent volume of saline. OA was induced by intra-articular injection of 3 mg MIA through the patellar ligament of the right knee. METHODS: Twenty-four male Sprague-Dawley rats were divided into four groups: Vehicle control (saline) monosodium iodoacetate-injection (MIA) LED irradiation after MIA injection (MIA-LED) indomethacin-treatment after MIA injection (MIA-IMT). PURPOSE: The purpose of this study was to evaluate whether light-emitting diodes (LED) irradiation could be effective in a noninvasive, therapeutic device for the treatment of osteoarthritis(OA).
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